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Alterations in Gene Expression in Human Mesothelial Cells Correlate with Mineral Pathogenicity

19 Dec 2008

Abstract excerpt

Human mesothelial cells (LP9/TERT-1) were exposed to low and high (15 and 75 microm(2)/cm(2) dish) equal surface area concentrations of crocidolite asbestos, nonfibrous talc, fine titanium dioxide (TiO2), or glass beads for 8 or 24 hours. RNA was then isolated for Affymetrix microarrays, GeneSifter analysis and QRT-PCR. Gene changes by asbestos were concentration- and time-dependent. At low nontoxic...

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PMID: 19097984
DOI: 10.1165/rcmb.2008-0146oc

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