Identification and characterization of a two-component regulatory system involved in invasion of eukaryotic cells and heavy-metal resistance in Burkholderia pseudomallei.

Abstract excerpt

Burkholderia pseudomallei is the causative agent of melioidosis, a disease increasingly recognized as an important cause of morbidity and mortality in many regions of the world. B. pseudomallei is a facultative intracellular pathogen capable of invading eukaryotic cells. We used Tn5-OT182 mutagen...

Topics

• Amino Acid Sequence
• Animals
• Burkholderia pseudomallei
• Cricetinae
• Drug Resistance, Microbial
• Humans
• Macrophages
• Melioidosis
• Metals, Heavy
• Molecular Sequence Data
• Mutagenesis
• Mutation