Article
Selection for spiral waves in the social amoebae Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Pálsson E, Lee K J, Goldstein R E, Franke J, Kessin R H, Cox E C
Abstract excerpt
Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium. Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Herein we test the essential features of this prediction by comparing wave propagation in wild...
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