Article
Does phenylethylamine have a role in schizophrenia?: LSD and PCP up-regulate aromatic L-amino acid decarboxylase mRNA levels.
Brain research. Molecular brain research - 3 Oct 1997
Buckland P R, Marshall R, Watkins P, McGuffin P
Abstract excerpt
Aromatic L-amino acid decarboxylase (AADC) is rate limiting in the production of 2-phenylethylamine (2PE). AADC activity and 2PE serum concentrations have been found to be increased in schizophrenic patients. Both antipsychotic and psychotogenic drugs, including amphetamine, affect the activity and encoding mRNA levels of AADC. Amphetamine is an analogue of 2PE and has a similar physiological effect. We have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.