Article
KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome.
Circulation - 4 Nov 1997
Donger C, Denjoy I, Berthet M, Neyroud N, Cruaud C, Bennaceur M, Chivoret G, Schwartz K, Coumel P, Guicheney P
Abstract excerpt
BACKGROUND: KVLQT1, the gene encoding the alpha-subunit of a cardiac potassium channel, is the most common cause of the dominant form of long-QT syndrome (LQT1-type), the Romano-Ward syndrome (RWS). The overall phenotype of RWS is characterized by a prolonged QT interval on the ECG and cardiac ve...
Topics
- Adult
- Electrocardiography
- Female
- Humans
- KCNQ Potassium Channels
- KCNQ1 Potassium Channel
- Long QT Syndrome
- Male
- Mutation
- Potassium Channels
- Potassium Channels, Voltage-Gated