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Article

Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 1997

Li J, Kasper D L, Ausubel F M, Rosner B, Michel J L

Abstract excerpt

The alpha C protein of group B Streptococcus (GBS) is a major surface-associated antigen. Although its role in the biology and virulence of GBS has not been defined, it is opsonic and capable of eliciting protective immunity. The alpha C protein is widely distributed among clinical isolates and is a potential protein carrier and antigen in conjugate vaccines to prevent GBS infections. The structural gene for the...

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Identifiers

PMID: 9371832
DOI: 10.1073/pnas.94.24.13251
PMCID: PMC24295

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