Article
Recombinant group B streptococcus Beta C protein and a variant with the deletion of its immunoglobulin A-binding site are protective mouse maternal vaccines and effective carriers in conjugate vaccines.
Infection and immunity - 1 Jul 2007
Yang Hsiao-Hui, Madoff Lawrence C, Guttormsen Hilde-Kari, Liu Yong-Dong, Paoletti Lawrence C
Abstract excerpt
Immunogenic vaccines against group B Streptococcus (GBS) have been created by coupling the GBS capsular polysaccharides (CPS) to carrier proteins. The GBS beta C protein (BCP) serves as an effective carrier while inducing protective immunity against BCP-expressing strains. BCP also binds human immunoglobulin A (IgA), a characteristic that may be undesirable for use in humans. Here, we examined the immunogenicity...
Topics
- Animals
- Animals, Newborn
- Animals, Outbred Strains
- Antibodies, Bacterial
- Antigens, Bacterial
- Bacterial Capsules
- Binding Sites
- Female
- Gene Deletion
- Genetic Variation
- HL-60 Cells
- Humans
- Immunity, Maternally-Acquired