Article
Thyroxine binding by human transthyretin variants: mutations at position 119, but not position 54, increase thyroxine binding affinity.
The Journal of clinical endocrinology and metabolism - 1 Feb 1994
Curtis A J, Scrimshaw B J, Topliss D J, Stockigt J R, George P M, Barlow J W
Abstract excerpt
A mutation at codon 119 in the transthyretin (TTR) gene leads to a substitution of methionine for threonine at this position in the circulating protein. As the amino acid at position 119 is located in the T4 binding channel, mutations here may affect the binding of T4 by TTR. A previous study has shown an increase in the amount of hormone carried by the TTRMet119 variant. To determine whether this increase in...
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