Thyroxine binding by human transthyretin variants: mutations at position 119, but not position 54, increase thyroxine binding affinity.

doi:10.1210/jcem.78.2.7906282

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Article

Thyroxine binding by human transthyretin variants: mutations at position 119, but not position 54, increase thyroxine binding affinity.

The Journal of clinical endocrinology and metabolism - 1 Feb 1994

Curtis A J, Scrimshaw B J, Topliss D J, Stockigt J R, George P M, Barlow J W

Abstract excerpt

A mutation at codon 119 in the transthyretin (TTR) gene leads to a substitution of methionine for threonine at this position in the circulating protein. As the amino acid at position 119 is located in the T4 binding channel, mutations here may affect the binding of T4 by TTR. A previous study has...

Topics

Genetic Variation
Glutamates
Glutamic Acid
Glycine
Humans
Infant
Methionine
Methods
Mutation
Prealbumin
Protein Binding
Threonine
Thyroxine

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