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Article

Thyroxine binding in a TTR Met 119 kindred.

The Journal of clinical endocrinology and metabolism - 1 Aug 1993

Alves I L, Divino C M, Schussler G C, Altland K, Almeida M R, Palha J A, Coelho T, Costa P P, Saraiva M J

Abstract excerpt

Recently, a transthyretin variant, TTR Met 119, in which methionine substitutes for threonine 119, a component of the protein's iodothyronine binding site, was identified in individuals with transient euthyroid hyperthyroxinemia. Healthy carriers of Met 119 have normal serum thyroid hormone concentrations, but two studies of Met 119 carriers have differed as to whether T4 binding to TTR is increased. An...

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Source

Identifiers

PMID: 8102146
DOI: 10.1210/jcem.77.2.8102146

Genes

TTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroxine binding in a TTR Met 119 kindred.PMID 8102146Read ↗

Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis.Semantic proximity Read ↗

Thyroxine binding by human transthyretin variants: mutations at position 119, but not position 54, increase thyroxine binding affinity.Semantic proximity Read ↗

A novel variant of transthyretin (prealbumin), Thr119 to Met, associated with increased thyroxine binding.Semantic proximity Read ↗

Screening and biochemical characterization of transthyretin variants in the Portuguese population.Semantic proximity Read ↗

From molecular variant to disease: initial steps in evaluating the association of transthyretin M119 with disease.Semantic proximity Read ↗

A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study.Semantic proximity Read ↗

Comparative stability and clearance of [Met30]transthyretin and [Met119]transthyretin.Semantic proximity Read ↗

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Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.Semantic proximity Read ↗

A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia.Semantic proximity Read ↗

A new transthyretin variant from a patient with familial amyloidotic polyneuropathy has asparagine substituted for histidine at position 90.Semantic proximity Read ↗

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