Thyroxine binding in a TTR Met 119 kindred.

doi:10.1210/jcem.77.2.8102146

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Article

Thyroxine binding in a TTR Met 119 kindred.

The Journal of clinical endocrinology and metabolism - 1 Aug 1993

Alves I L, Divino C M, Schussler G C, Altland K, Almeida M R, Palha J A, Coelho T, Costa P P, Saraiva M J

Abstract excerpt

Recently, a transthyretin variant, TTR Met 119, in which methionine substitutes for threonine 119, a component of the protein's iodothyronine binding site, was identified in individuals with transient euthyroid hyperthyroxinemia. Healthy carriers of Met 119 have normal serum thyroid hormone conce...

Topics

Amyloidosis
Asparagine
Binding Sites
DNA
Female
Genotype
Heterozygote
Humans
Hyperthyroxinemia
Isoelectric Focusing
Male
Methionine
Nervous System Diseases
Pedigree
Point Mutation
Polymorphism, Restriction Fragment Length
Portugal
Prealbumin

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PMID: 8102146
DOI: 10.1210/jcem.77.2.8102146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8102146-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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