Article
Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1.
Oncogene - 18 Apr 1996
Theodorakis P, D'Sa-Eipper C, Subramanian T, Chinnadurai G
Abstract excerpt
The BHRF1 protein of Epstein-Barr virus (EBV) is a structural and functional homolog of the Bcl-2 protein. Both BHRF1 and Bcl-2 proteins promote the survival of cells exposed to various apoptotic stimuli. This promotion of cell survival is associated with a block in proliferation. It is believed...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Bacterial Proteins
- Cell Division
- Cell Line, Transformed
- Cell Survival
- Cell Transformation, Neoplastic
- Herpesvirus 4, Human
- Kidney
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Peptide Synthases
- Precipitin Tests
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
