Article
Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1.
Oncogene - 18 Apr 1996
Theodorakis P, D'Sa-Eipper C, Subramanian T, Chinnadurai G
Abstract excerpt
The BHRF1 protein of Epstein-Barr virus (EBV) is a structural and functional homolog of the Bcl-2 protein. Both BHRF1 and Bcl-2 proteins promote the survival of cells exposed to various apoptotic stimuli. This promotion of cell survival is associated with a block in proliferation. It is believed that the Bcl-2 family of anti-apoptosis proteins contribute to oncogenesis merely by promoting cell survival. We have...
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