Article
BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation.
Oncogene - 5 Jan 1995
Dawson C W, Eliopoulos A G, Dawson J, Young L S
Abstract excerpt
Epstein-Barr virus (EBV) is associated with tumours of both lymphoid and epithelial origin. Whilst a role for EBV latent genes in the development of these malignancies is accepted, it is also possible that viral proteins involved in EBV replication may influence the oncogenic process. BHRF1 is an immediate early protein which has homology with the Bcl-2 oncogene and can protect B cells from apoptosis. In vivo...
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