BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation.

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Article

BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation.

Oncogene - 5 Jan 1995

Dawson C W, Eliopoulos A G, Dawson J, Young L S

Abstract excerpt

Epstein-Barr virus (EBV) is associated with tumours of both lymphoid and epithelial origin. Whilst a role for EBV latent genes in the development of these malignancies is accepted, it is also possible that viral proteins involved in EBV replication may influence the oncogenic process. BHRF1 is an...

Topics

Apoptosis
Carcinoma, Squamous Cell
Cell Differentiation
Cell Survival
Cisplatin
Culture Media, Serum-Free
Epithelial Cells
Herpesvirus 4, Human
Humans
Phenotype
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Transfection
Tumor Cells, Cultured
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 7824280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7824280-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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