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A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog

22 Jan 2016

Abstract excerpt

The Epstein-Barr virus (EBV) infects and transforms B-lymphocytes with high efficiency. This process requires expression of the viral latent proteins and of the 3 miR-BHRF1 microRNAs. Here we show that B-cells infected by a virus that lacks these non-coding RNAs (Δ123) grew more slowly between day 5 and day 20, relative to wild type controls. This effect could be ascribed to a reduced S phase entry combined with...

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PMID: 26800049
DOI: 10.1371/journal.ppat.1005405

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