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Article

Differential induction of cytotoxicity and apoptosis by influenza virus strains of differing virulence.

1 Nov 1997

Abstract excerpt

Two influenza viruses of differing virulence, clone 7a (virulent for humans and ferrets) and A/Fiji (attenuated for both species), induced differential levels of cytotoxicity (as measured by release of lactate dehydrogenase from cells) and apoptosis (as determined by altered nuclear morphology or flow cytometry) in MDCK and U-937 cells. Clone 7a induced more apoptosis and cytotoxicity than A/Fiji, despite the...

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PMID: 9367368
DOI: 10.1099/0022-1317-78-11-2821

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