Article
The spectrum of beta-thalassaemia mutations in the Lebanon.
Human heredity - 1 Jan 2000
Zahed L, Talhouk R, Saleh M, Abou-Jaoudeh R, Fisher C, Old J
Abstract excerpt
We screened 110 DNA samples from carriers of beta-thalassaemia, using the ARMS-PCR technique with primers for common Mediterranean mutations. Unidentified samples were subjected to a heteroduplex analysis with Universal Heteroduplex Generators covering the beta-globin gene, followed by DNA sequencing. In total, 16 different mutations were detected, the most frequent being IVSI-110 (40%), followed by other common...
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