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Article

Trisomy 21 Placentas: Histopathological and Immunohistochemical Findings using Proliferating Cell Nuclear Antigen

27 Nov 2009

Abstract excerpt

OBJECTIVE: The cause of growth retardation in trisomy 21 and other autosomal trisomies is not known, but may be the result of defective cell proliferation, slowing of the cell cycle, or placental structural abnormalities. Abnormalities of the fetal cell cycle may be reflected in placental growth and can be detected using proliferating cell nuclear antigen (PCNA). METHODS: Twelve second-trimester and six...

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PMID: 9354879
DOI: 10.1159/000264470

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