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Article

Morphologic and GATA1 sequencing analysis of hematopoiesis in fetuses with trisomy 21.

Human pathology - 1 May 2014

Hoeller Sylvia, Bihl Michel P, Tzankov Alexandar, Chaffard Rosemarie, Hirschmann Petra, Miny Peter, Kühne Thomas, Bruder Elisabeth

Abstract excerpt

Trisomy 21 alters fetal liver hematopoiesis and, in combination with somatic globin transcription factor 1 (GATA1) mutations, leads to development of transient myeloproliferative disease in newborns. However, little is known about the morphological hematopoietic changes caused by trisomy 21 in the fetus, and to date, the exact onset of GATA1 mutations remains uncertain. Therefore, we analyzed fetal liver...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Megakaryoblastic, Acute

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Share to Pregnancy Trimester, Second

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Source

Identifiers

PMID: 24746204
DOI: 10.1016/j.humpath.2013.12.014

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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