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Article

APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome.

Archives of medical research - 1 May 2007

Miller Michael, Rhyne Jeffrey, Chen Hegang, Beach Valerie, Ericson Richard, Luthra Kalpana, Dwivedi Manjari, Misra Anoop

Abstract excerpt

BACKGROUND: Despite the growing epidemic of the metabolic syndrome (MetS), few studies have evaluated genetic polymorphisms associated with the MetS phenotype. One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of...

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Topics

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Share to Apolipoprotein C-III
Share to APOC3 gene
Share to FABP2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 17416293
DOI: 10.1016/j.arcmed.2006.10.013
PMCID: PMC1987381

Genes

APOC3
APOE
FABP2
GNB3
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17416293-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome.PMID 17416293Read ↗

Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample.Semantic proximity Read ↗

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.Semantic proximity Read ↗

[Association between APOC3 promoter region polymorphisms and non-alcoholic fatty liver disease].Semantic proximity Read ↗

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.Semantic proximity Read ↗

Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects.Semantic proximity Read ↗

Associations of the APOC3 rs5128 polymorphism with plasma APOC3 and lipid levels: a meta-analysis.Semantic proximity Read ↗

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Association of an APOC3 promoter variant with type 2 diabetes risk and need for insulin treatment in lean persons.Semantic proximity Read ↗

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Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II).Semantic proximity Read ↗

A CpG-SNP Located within the ARPC3 Gene Promoter Is Associated with Hypertriglyceridemia in Severely Obese Patients.Semantic proximity Read ↗

Beneficial metabolic phenotypes caused by loss-of-function APOC3 mutations.Semantic proximity Read ↗

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