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Article

Clonal descent and microevolution of Neisseria meningitidis during 30 years of epidemic spread.

Molecular microbiology - 1 Sept 1997

Morelli G, Malorny B, Müller K, Seiler A, Wang J F, del Valle J, Achtman M

Abstract excerpt

Serogroup A meningococci of subgroups III, IV-1 and IV-2 are probably descended from a common ancestor that existed in the nineteenth century. The 10.5kb sequences spanning five distinct chromosomal loci, encoding cell-surface antigens, a secreted protease or housekeeping genes and intergenic regions, were almost identical in strains of those subgroups isolated in 1966, 1966 and 1917 respectively. During the...

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PMID: 9350862
DOI: 10.1046/j.1365-2958.1997.5211882.x

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