Article
A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA-A*01 allele.
Tissue antigens - 1 Oct 1997
Laforet M, Froelich N, Parissiadis A, Pfeiffer B, Schell A, Faller B, Woehl-Jaegle M L, Cazenave J P, Tongio M M
Abstract excerpt
HLA class I typing performed in parallel by molecular biology and serology has revealed cases where an HLA class I allele was identified whereas the corresponding antigen was not detected on the cell surface. In the present report, we describe four members of a family in whom an HLA-A1 allele ide...
Topics
- Alleles
- Codon
- DNA Mutational Analysis
- Exons
- Female
- Frameshift Mutation
- Gene Expression
- Genes, MHC Class I
- HLA-A1 Antigen
- Histocompatibility Testing
- Humans
- Kidney Transplantation
- Male
- Molecular Sequence Data
- Mutagenesis, Insertional
- Polymerase Chain Reaction
- Sequence Alignment
- Sequence Homology, Nucleic Acid