Article
Different susceptibilities of genetic variants of hepatitis C virus (HCV) to interferon (IFN).
Archives of virology - 1 Jan 1997
Lu M, Wiese M, Funsch B, Roggendorf M
Abstract excerpt
Genetic variants of HCV may have different degrees of resistance to IFN and may therefore influence the outcome of IFN therapy. However, selection of HCV variants by IFN has not been investigated in detail. In this paper, heteroduplex analysis was used to monitor major changes of HCV populations in 4 chronically infected patients under IFN therapy. We found that a major variant of the HCV 5' non-coding region (5'...
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