Article
A gene essential for de novo methylation and development in Ascobolus reveals a novel type of eukaryotic DNA methyltransferase structure.
Cell - 17 Oct 1997
Malagnac F, Wendel B, Goyon C, Faugeron G, Zickler D, Rossignol J L, Noyer-Weidner M, Vollmayr P, Trautner T A, Walter J
Abstract excerpt
Molecular mechanisms determining methylation patterns in eukaryotic genomes still remain unresolved. We have characterized, in Ascobolus, a gene for de novo methylation. This novel eukaryotic gene, masc1, encodes a protein that has all motifs of the catalytic domain of eukaryotic C5-DNA-methyltransferases but is unique in that it lacks a regulatory N-terminal domain. The disruption of masc1 has no effect on...
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