Article
A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Nov 2005
Chandra Saurabh, Levran Orna, Jurickova Ingrid, Maas Chiel, Kapur Rick, Schindler Detlev, Henry Rashida, Milton Kelly, Batish Sat Dev, Cancelas Jose A, Hanenberg Helmut, Auerbach Arleen D, Williams David A
Abstract excerpt
Fanconi anemia (FA) is a rare autosomal recessive disorder that results from mutations in at least 11 different genes. Recent studies have demonstrated that clinical progression of the disease may be influenced by inter- and intragenic variations, emphasizing the importance of identifying the complementation groups. In the present study we have employed bicistronic retrovirus vectors that coexpress FA-specific...
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