Power and sample size calculations for case-control studies of gene-environment interactions with a polytomous exposure variable.

Abstract excerpt

Genetic polymorphisms may appear to the epidemiologist most commonly as different levels of susceptibility to exposure. Epidemiologic studies of heterogeneity in exposure susceptibility aim at estimating the parameter quantifying the gene-environment interaction. In this paper, the authors use a general approach to power and sample size calculations for case-control studies, which is applicable to settings where...

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