Article
Apolipoprotein E gene polymorphism in early and late onset bipolar patients.
Neuroscience letters - 12 Sept 1997
Bellivier F, Laplanche J L, Schürhoff F, Feingold J, Féline A, Jouvent R, Launay J M, Leboyer M
Abstract excerpt
To explore the involvement of apolipoprotein E gene (APO E) in major depression, we studied the APO E gene polymorphism in a sample of 156 unrelated bipolar patients and 91 healthy volunteers. This population was stratified for age at onset of the affective disorder (onset before 18 years, after 45 years and between 18 and 45 years). Early onset bipolar patients with psychotic symptoms exhibited a significant...
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