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Article

Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system.

Bipolar disorders - 1 Mar 2009

Severino Giovanni, Manchia Mirko, Contu Paolo, Squassina Alessio, Lampus Simona, Ardau Raffaella, Chillotti Caterina, Del Zompo Maria

Abstract excerpt

OBJECTIVE: The aim of our study was to investigate the association between REV-ERBalpha gene (NR1D1) single nucleotide polymorphisms (SNPs) and bipolar disorder (BP) in a case-control sample of Sardinian ancestry and evaluate its effect on age at onset (AAO) of BP. METHODS: We genotyped SNPs rs12941497 (SNP1) and rs939347 (SNP2), located, respectively, in the first intron and in the 5'UTR region of the gene, in a...

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PMID: 19267705
DOI: 10.1111/j.1399-5618.2009.00667.x

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