Article
Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system.
Bipolar disorders - 1 Mar 2009
Severino Giovanni, Manchia Mirko, Contu Paolo, Squassina Alessio, Lampus Simona, Ardau Raffaella, Chillotti Caterina, Del Zompo Maria
Abstract excerpt
OBJECTIVE: The aim of our study was to investigate the association between REV-ERBalpha gene (NR1D1) single nucleotide polymorphisms (SNPs) and bipolar disorder (BP) in a case-control sample of Sardinian ancestry and evaluate its effect on age at onset (AAO) of BP. METHODS: We genotyped SNPs rs12...
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