Apolipoprotein epsilon 4 homozygosity in young men with coronary heart disease.

Abstract excerpt

We have compared apolipoprotein E gene polymorphism in 91 Australian men aged 30-50 who had been referred for coronary angioplasty and in 172 healthy younger men. 5 of the 19 patients who were less than 40 years of age were homozygous for the epsilon 4 allele, representing a 16-fold increase in prevalence compared with controls. In patients aged 40-50 the epsilon 4 allele frequency was 60% higher than it was in...

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