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Article

Allelotype of pediatric rhabdomyosarcoma.

Oncogene - 1 Sept 1997

Visser M, Sijmons C, Bras J, Arceci R J, Godfried M, Valentijn L J, Voûte P A, Baas F

Abstract excerpt

An allelotype covering all autosomes was constructed for the embryonal form of childhood rhabdomyosarcoma (ERMS) in order to identify regions encompassing tumorsuppressor genes (TSG) involved in ERMS. Thusfar most studies were focussed on chromosome 11p15.5, which frequently shows loss of heterozygozity (LOH) in embryonal tumors like RMS and Wilms' tumor (WT). In this study we show that, besides LOH of chromosome...

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PMID: 9315099
DOI: 10.1038/sj.onc.1201302

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IGF2

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