Article
Investigation of promoter polymorphisms in the tumor necrosis factor-alpha and interleukin-10 genes in liver transplant patients.
Transplantation - 27 Jun 2002
Fernandes Helen, Koneru Baburao, Fernandes Neil, Hameed Meera, Cohen Marion C, Raveche Elizabeth, Cohen Stanley
Abstract excerpt
BACKGROUND: Cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 play significant roles in the inflammatory and immune responses that mediate allograft rejection. The presence of a G-->A polymorphism at position -308 in the promoter region of the TNF-alpha gene increased its transcription 6- to 7-fold. A similar polymorphism at position -1082 of the IL-10 promoter results in decreased...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.