Article
[Is heterozygote alpha 1-antitrypsin deficiency a risk factor in the etiology of aortic aneurysm?].
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen - 1 May 1997
Hernandez-Richter T, Schardey H M, Klueppelberg U, Tutsch-Bauer E, Lauterjung L, Schildberg F W
Abstract excerpt
A potential role of homozygous or heterozygous alpha-1-antitrypsin deficiency alleles Pi*Z or Pi*S in the pathogenesis of aortic aneurysms has been debated in recently published papers. Therefore, we have determined the alpha-1-antitrypsin phenotype in 103 patients with aortic aneurysms using isoelectric focusing. The vast majority of patients (92.2%) had one or more of the established risk factors: hypertension...
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