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[Screening for cerebral aneurysms in the ADPKD population: mandatory or potentially harmful?].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia - 1 Jan 2000

Magistroni Riccardo, Palmieri Lucia, Scolari Francesco

Abstract excerpt

Cerebral aneurysm in autosomal dominant polycystic kidney disease (ADPKD) is an uncommon event (documented in 6-13% of cases) but frequently characterized by severe neurological sequelae and potentially fatal in case of rupture. The arterial vascular wall of the anterior cerebral circulation is most frequently involved. Experimental data showed the expression of polycystins (the proteins modified by the mutation...

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PMID: 22167609

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