Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.

Science (New York, N.Y.) - 26 Sept 1997

DiFiglia M, Sapp E, Chase K O, Davies S W, Bates G P, Vonsattel J P, Aronin N

Abstract excerpt

The cause of neurodegeneration in Huntington's disease (HD) is unknown. Patients with HD have an expanded NH2-terminal polyglutamine region in huntingtin. An NH2-terminal fragment of mutant huntingtin was localized to neuronal intranuclear inclusions (NIIs) and dystrophic neurites (DNs) in the HD cortex and striatum, which are affected in HD, and polyglutamine length influenced the extent of huntingtin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Nucleus

Share to Fluorescent Antibody Technique

Share to Mutation

Share to Nerve Tissue Proteins

Share to Neurons

Source

Identifiers

PMID: 9302293
DOI: 10.1126/science.277.5334.1990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.PMID 9302293Read ↗

Huntingtin processing in pathogenesis of Huntington disease.Semantic proximity Read ↗

Huntington's Disease Intranuclear Inclusions Contain Truncated, Ubiquitinated Huntingtin ProteinSemantic proximity Read ↗

Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset.Semantic proximity Read ↗

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity.Semantic proximity Read ↗

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.Semantic proximity Read ↗

Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington’s disease human cerebral cortexSemantic proximity Read ↗

Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease MiceSemantic proximity Read ↗

From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington'sdiseaseSemantic proximity Read ↗

Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation.Semantic proximity Read ↗

Protein aggregates in Huntington's disease.Semantic proximity Read ↗

Axonal Transport of N-terminal Huntingtin Suggests Early Pathology of Corticostriatal Projections in Huntington DiseaseSemantic proximity Read ↗

Neuronal intranuclear hyaline inclusion diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.