Article
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
Science (New York, N.Y.) - 26 Sept 1997
DiFiglia M, Sapp E, Chase K O, Davies S W, Bates G P, Vonsattel J P, Aronin N
Abstract excerpt
The cause of neurodegeneration in Huntington's disease (HD) is unknown. Patients with HD have an expanded NH2-terminal polyglutamine region in huntingtin. An NH2-terminal fragment of mutant huntingtin was localized to neuronal intranuclear inclusions (NIIs) and dystrophic neurites (DNs) in the HD...
Topics
- Adolescent
- Adult
- Aged
- Blotting, Western
- Brain Chemistry
- Cell Nucleus
- Cerebral Cortex
- Corpus Striatum
- Fluorescent Antibody Technique
- Humans
- Huntingtin Protein
- Huntington Disease
- Immunoenzyme Techniques
- Middle Aged
- Mutation
- Nerve Tissue Proteins
- Neurites
- Neurons