Article
Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset.
Neuroreport - 1 Jun 1998
Gourfinkel-An I, Cancel G, Duyckaerts C, Faucheux B, Hauw J J, Trottier Y, Brice A, Agid Y, Hirsch E C
Abstract excerpt
Neuronal intranuclear inclusions were recently found in the brain of patients with inherited neurodegenerative disorders characterized by the expansion of a polyglutamine stretch in the mutated protein. These inclusions are ubiquitinated and, for some of these diseases, the presence of the mutated protein could be also identified. Using immunohistochemistry, we show here that ubiquitinated intranuclear inclusions...
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