Article
Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset.
Neuroreport - 1 Jun 1998
Gourfinkel-An I, Cancel G, Duyckaerts C, Faucheux B, Hauw J J, Trottier Y, Brice A, Agid Y, Hirsch E C
Abstract excerpt
Neuronal intranuclear inclusions were recently found in the brain of patients with inherited neurodegenerative disorders characterized by the expansion of a polyglutamine stretch in the mutated protein. These inclusions are ubiquitinated and, for some of these diseases, the presence of the mutate...
Topics
- Adult
- Age of Onset
- Antibodies, Monoclonal
- Case-Control Studies
- Cell Nucleus
- Humans
- Huntingtin Protein
- Huntington Disease
- Immunohistochemistry
- Inclusion Bodies
- Middle Aged
- Mutation