Article
Single cell detection of beta-thalassaemia mutations using silver stained SSCP analysis: an application for preimplantation diagnosis.
Molecular human reproduction - 1 Aug 1997
el-Hashemite N, Wells D, Delhanty J D
Abstract excerpt
Although prenatal diagnosis has reduced the number of beta-thalassaemia births, pregnancy termination is still unacceptable for many couples. Preimplantation genetic diagnosis carried out on the third day after in-vitro fertilization offers an alternative. Here we describe the detection of select...
Topics
- Alleles
- Base Sequence
- Blastomeres
- Coloring Agents
- DNA Primers
- Exons
- Female
- Genetic Carrier Screening
- Globins
- Homozygote
- Humans
- Introns
- Mutation