Article
On the nature of hereditary cataract in strain 13/N guinea pigs.
Current eye research - 1 Sept 1997
Bettelheim F A, Churchill A C, Zigler J S
Abstract excerpt
PURPOSE: Congenital nuclear cataracts in strain 13/N guinea pigs are caused by a single splice-site mutation in the zeta-crystallin gene. Very little is known of the physical factors involved in lens opacification of this system. The aim of this study is to elucidate the biophysical processes causing the nuclear turbidity. METHODS: Normal, homozygous and heterozygous mutant guinea pig lenses were studied....
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