Association of hereditary cataracts in strain 13/N guinea-pigs with mutation of the gene for zeta-crystallin.

doi:10.1016/0014-4835(90)90217-i

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Article

Association of hereditary cataracts in strain 13/N guinea-pigs with mutation of the gene for zeta-crystallin.

Experimental eye research - 1 Mar 1990

Huang Q L, Du X Y, Stone S H, Amsbaugh D F, Datiles M, Hu T S, Zigler J S

Abstract excerpt

Congenital nuclear cataracts transmitted by an autosomal dominant gene are present in a line of strain 13/N guinea-pigs. Studies on the lens proteins from these animals demonstrate changes in both the composition and structure of the crystallins relative to normal controls. The most prominent difference is in the zeta-crystallin, a taxon-specific crystallin which has been shown to be related to the alcohol...

Topics

Animals
Cataract
Crystallins
Guinea Pigs
Heterozygote
Lens, Crystalline
Mutation

Identifiers

PMID: 2318275
DOI: 10.1016/0014-4835(90)90217-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2318275-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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