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Article

The ageing lens and cataract: a model of normal and pathological ageing

14 Mar 2011

Abstract excerpt

Cataract is a visible opacity in the lens substance, which, when located on the visual axis, leads to visual loss. Age-related cataract is a cause of blindness on a global scale involving genetic and environmental influences. With ageing, lens proteins undergo non-enzymatic, post-translational modification and the accumulation of fluorescent chromophores, increasing susceptibility to oxidation and cross-linking...

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PMID: 21402586
DOI: 10.1098/rstb.2010.0300

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