Article
Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3.
Genomics - 15 Aug 1997
Heuckeroth R O, Kotzbauer P, Copeland N G, Gilbert D J, Jenkins N A, Zimonjic D B, Popescu N C, Johnson E M, Milbrandt J
Abstract excerpt
Neurturin is a potent neurotrophic factor closely related to glial cell line-derived neurotrophic factor (GDNF, 40% amino acid sequence identity) and, like GDNF, can promote the survival of numerous neuronal populations including sympathetic, nodose, and dorsal root ganglion sensory neurons. Both neurturin and GDNF signal through the Ret tyrosine kinase and require a glycosylphosphatidylinositol-linked...
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