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Article

The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathways.

Genes & development - 1 Aug 1997

Connolly L, De Las Penas A, Alba B M, Gross C A

Abstract excerpt

The activity of the alternate sigma-factor sigmaE of Escherichia coli is induced by several stressors that lead to the extracytoplasmic accumulation of misfolded or unfolded protein. The sigmaE regulon contains several genes, including that encoding the periplasmic protease DegP, whose products are thought to be required for maintaining the integrity of the cell envelope because cells lacking sigmaE are sensitive...

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Identifiers

PMID: 9271123
DOI: 10.1101/gad.11.15.2012
PMCID: PMC316410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathways.PMID 9271123Read ↗

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Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.Semantic proximity Read ↗

Activation of the Cpx Envelope Stress Response Down-Regulates Expression of Several Locus of Enterocyte Effacement-Encoded Genes in Enteropathogenic Escherichia coliSemantic proximity Read ↗

A suppressor of cell death caused by the loss of sigmaE downregulates extracytoplasmic stress responses and outer membrane vesicle production in Escherichia coli.Semantic proximity Read ↗

DegP is involved in Cpx-mediated posttranscriptional regulation of the type III secretion apparatus in enteropathogenic Escherichia coli.Semantic proximity Read ↗

Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses.Semantic proximity Read ↗

Fine-Tuning of the Cpx Envelope Stress Response Is Required for Cell Wall Homeostasis in Escherichia coli.Semantic proximity Read ↗

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The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP.Semantic proximity Read ↗

Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system.Semantic proximity Read ↗

Overproduction of NlpE, a new outer membrane lipoprotein, suppresses the toxicity of periplasmic LacZ by activation of the Cpx signal transduction pathway.Semantic proximity Read ↗

One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery.Semantic proximity Read ↗

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