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Article

The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP.

Genes & development - 15 Feb 1995

Danese P N, Snyder W B, Cosma C L, Davis L J, Silhavy T J

Abstract excerpt

DegP is a heat-shock inducible periplasmic protease in Escherichia coli. Unlike the cytoplasmic heat shock proteins, DegP is not transcriptionally regulated by the classical heat shock regulon coordinated by sigma 32. Rather, the degP gene is transcriptionally regulated by an alternate heat shock sigma factor, sigma E. Previous studies have demonstrated a signal transduction pathway that monitors the amount of...

Topics

Bacterial Proteins
Base Sequence
Cell Membrane
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Heat-Shock Proteins
Lac Operon
Lipoproteins
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Molecular Sequence Data

Mutation

Organophosphates

Periplasmic Proteins

Protein Kinases

Recombinant Fusion Proteins

Serine Endopeptidases

Source

Identifiers

PMID: 7883164
DOI: 10.1101/gad.9.4.387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7883164-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP.PMID 7883164Read ↗

Transduction of envelope stress in Escherichia coli by the Cpx two-component system.Semantic proximity Read ↗

Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.Semantic proximity Read ↗

Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses.Semantic proximity Read ↗

Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system.Semantic proximity Read ↗

DegP is involved in Cpx-mediated posttranscriptional regulation of the type III secretion apparatus in enteropathogenic Escherichia coli.Semantic proximity Read ↗

Structure of the periplasmic stress response protein CpxP.Semantic proximity Read ↗

Cpx two-component signal transduction in Escherichia coli: excessive CpxR-P levels underlie CpxA* phenotypes.Semantic proximity Read ↗

The Cpx envelope stress response affects expression of the type IV bundle-forming pili of enteropathogenic Escherichia coli.Semantic proximity Read ↗

Absence of the outer membrane phospholipase A suppresses the temperature-sensitive phenotype of Escherichia coli degP mutants and induces the Cpx and sigma(E) extracytoplasmic stress responses.Semantic proximity Read ↗

[Mutation of the envelope stress-responsive protein CpxA capable of regulating the antimicrobial resistance and virulence of bacteria].Semantic proximity Read ↗

The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathways.Semantic proximity Read ↗

Fine-Tuning of σE Activation Suppresses Multiple Assembly-Defective Mutations in Escherichia coli.Semantic proximity Read ↗

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