Article
Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians.
Diabetologia - 1 Aug 1997
McDermott M F, Ramachandran A, Ogunkolade B W, Aganna E, Curtis D, Boucher B J, Snehalatha C, Hitman G A
Abstract excerpt
Vitamin D has important immunomodulatory properties and prevents development of diabetes mellitus in an animal model of insulin-dependent diabetes (IDDM). We have studied the vitamin D receptor locus as a candidate for genetic susceptibility to IDDM in Southern Indian families. We found evidence for an association of one particular vitamin D receptor allele with IDDM susceptibility in this community. Ninety-three...
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