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Article

The vitamin D receptor TaqI TT genotype is associated with type 1 diabetes in the Black South African population.

Journal of nutritional science - 1 Jan 2024

Bhola Sureka, Cave Eleanor M, Prigge Katherine L, Bhana Sindeep, Crowther Nigel J, Padoa Carolyn J

Abstract excerpt

Polymorphisms in the vitamin D receptor (VDR) gene (BsmI (rs1544410), FokI (rs2228570), ApaI (rs7975232), TaqI (rs731236)) and low vitamin D concentrations have previously been associated with type 1 diabetes (T1D). Vitamin D is thought to mediate the switch from a pro-inflammatory Th1 response to an anti-inflammatory Th2 response which is protective against the development of T1D. These associations are...

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Share to Black People
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Share to Diabetes Mellitus, Type 1
Share to Polymorphism, Restriction Fragment Length
Share to Receptors, Calcitriol
Share to South Africa
Share to Vitamin D
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Source

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Identifiers

PMID: 39703896
DOI: 10.1017/jns.2024.77
PMCID: PMC11658941

Genes

VDR
CYP24A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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