Article
Impaired Cell Proliferation in Mice That Persists across at Least Two Generations after Paternal Irradiation
1 Aug 1997
Abstract excerpt
Irradiation of male F0 mice 6 to 7 weeks prior to mating causes significant changes in the proliferation of F1 and F2 embryonic cells. These changes are revealed as a competitive cell proliferation disadvantage in chimera assays when the affected embryo is paired with a normal embryo in an aggregation chimera. This effect has been observed previously to be transmitted to F1 embryos for absorbed doses from 0.01 to...
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