Article
[Search for expansion of CAG-repeats in DNA sequences expressed in the brain of humans with psychiatric and neurological diseases].
Voprosy meditsinskoi khimii - 1 Jan 2000
Ovchinnikov I V, Braga E A, Aksenova M G, Druzina E B, Ovchinnikova O I, Illarioshkin S N, Kaleda V G, Markova E D, Ivanova-Smolenskaia I A
Abstract excerpt
Dynamic mutations due to trinucleotide repeat expansion are a new class of human genome mutations. CAG repeat expansion in the coding region of associated genes is the molecular genetic basis of the several diseases of nervous system. Eight DNA sequences with CAG repeats expressed in human brain were chosen from the GenBank database. The search of CAG expansion was carried out for patients with schizophrenia...
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