Article
Human sperm cytosolic factor triggers Ca2+ oscillations and overcomes activation failure of mammalian oocytes
1 Apr 1997
Abstract excerpt
Among the possible mechanisms of oocyte activation after sperm penetration, it appears most likely that a protein released by the spermatozoon elicits a calcium elevation in the ooplasm. To further test this idea, cytosolic factors obtained from human spermatozoa by two different methods, freezing-thawing and sonication, were injected into mouse oocytes following which intracellular calcium release was measured....
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