Article
The Han:SPRD rat is not a genetic model of human autosomal dominant polycystic kidney disease type 1.
Laboratory animals - 1 Jul 1997
Nauta J, Goedbloed M A, Luider T M, Hoogeveen A T, van den Ouweland A M, Halley D J
Abstract excerpt
Human autosomal dominant polycystic kidney disease (ADPKD) is a high incidence disorder leading to renal failure in many patients. The majority of cases results from a mutation in the PKD1 gene. The only well documented animal model of ADPKD is the Han:SPRD-Pkd strain. Its genetic basis is unknown as yet. In the current study we determined whether the disease in these rats is genetically linked to the rat...
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