Article
Radiation and genetic factors in the risk of second malignant neoplasms after a first cancer in childhood.
Lancet (London, England) - 12 Jul 1997
Kony S J, de Vathaire F, Chompret A, Shamsaldim A, Grimaud E, Raquin M A, Oberlin O, Brugières L, Feunteun J, Eschwège F, Chavaudra J, Lemerle J, Bonaïti-Pellié C
Abstract excerpt
BACKGROUND: Radiotherapy and chemotherapy are associated with an increased risk of second malignant neoplasm (SMN). An association between SMN and familial aggregation has also been shown. The aim of this study was to investigate the role of familial factors in the risk of SMN and their potential interaction with the effect of treatment. METHODS: We devised a case-control study of 25 children with SMN (cases) and...
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