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Article

Renal cell regeneration following oxidant exposure: inhibition by TGF-beta1 and stimulation by ascorbic acid.

Toxicology and applied pharmacology - 1 Jul 1997

Nowak G, Schnellmann R G

Abstract excerpt

Renal proximal tubular cell (RPTC) monolayers exposed to the model oxidant tert-butylhydroperoxide (TBHP; 0.8 mM) for 1.5 hrs were 33 and 31% confluent after 1 and 4 days, respectively. Control monolayers remained 100% confluent throughout the experiment. Exogenous TGF-beta1 promoted monolayer deterioration by potentiating cellular death and suppressed EGF-stimulated regeneration of the RPTC monolayer. Net...

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Identifiers

PMID: 9221835
DOI: 10.1006/taap.1997.8166

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EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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