Article
A Neisseria gonorrhoeae immunoglobulin A1 protease mutant is infectious in the human challenge model of urethral infection.
Infection and immunity - 1 Jun 1999
Johannsen D B, Johnston D M, Koymen H O, Cohen M S, Cannon J G
Abstract excerpt
Many mucosal pathogens, including Neisseria gonorrhoeae, produce proteases that cleave immunoglobulin A (IgA), the predominant immunoglobulin class produced at mucosal surfaces. While considerable circumstantial evidence suggests that IgA1 protease contributes to gonococcal virulence, there is no direct evidence that N. gonorrhoeae requires IgA1 protease activity to infect a human host. We constructed a N....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.