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Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants

11 Jun 2012

Abstract excerpt

Telomeres are repeating DNA sequences at the ends of chromosomes that protect and buffer genes from nucleotide loss as cells divide. Telomere length (TL) shortens with age in most proliferating tissues, limiting cell division and thereby contributing to senescence. However, TL increases with age in sperm, and, correspondingly, offspring of older fathers inherit longer telomeres. Using data and samples from a...

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Birth, Development, and Health
Genetics, Aging, and Longevity in Model Organisms
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22689985
DOI: 10.1073/pnas.1202092109

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