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Article

Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours.

Human genetics - 1 Jan 1994

Crossey P A, Foster K, Richards F M, Phipps M E, Latif F, Tory K, Jones M H, Bentley E, Kumar R, Lerman M I

Abstract excerpt

Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome characterised by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma (RCC), phaeochromocytoma and pancreatic tumours. The VHL disease gene maps to chromosome 3p25-p26. To investigate the mechanism of tumourigenesis in VHL disease, we analysed 24 paired blood/tumour DNA samples from 20 VHL...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8270255
DOI: 10.1007/BF00218913

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours.PMID 8270255Read ↗

Molecular genetic analysis of von Hippel-Lindau disease.Semantic proximity Read ↗

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Reconsideration of biallelic inactivation of the VHL tumour suppressor gene in hemangioblastomas of the central nervous system.Semantic proximity Read ↗

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype.Semantic proximity Read ↗

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