Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours.

doi:10.1007/BF00218913

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Article

Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours.

Human genetics - 1 Jan 1994

Crossey P A, Foster K, Richards F M, Phipps M E, Latif F, Tory K, Jones M H, Bentley E, Kumar R, Lerman M I

Abstract excerpt

Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome characterised by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma (RCC), phaeochromocytoma and pancreatic tumours. The VHL disease gene maps to chromosome 3p25-p26. To...

Topics

Alleles
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 3
DNA, Neoplasm
Genes, Tumor Suppressor
Genetic Linkage
Heterozygote
Humans
Molecular Biology
Neoplasms
von Hippel-Lindau Disease

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PMID: 8270255
DOI: 10.1007/BF00218913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8270255-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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